CPM Note:
As the Center for Precision Medicine prepares to host summer students, and prepares for the return to work of faculty and staff currently working remotely, I would like to remind everyone that WFBH has reiterated the continued need for wearing masks [a list of approved types, and how to wear them, is available on the WFBH website]. This includes wearing masks in ALL spaces outside of our immediate offices or cubicles, hallways, conference rooms, kitchen, and spaces proximal to the Center and the building. Please adhere to these rules regarding masks, recognizing that we all serve as role models for our new CPM students and ensuring that the Center remains a safe and supportive place to work for all!
Return to Work Information
Update: Return to On-site Postponed Teammates, Thank you for everything you are doing as we face an ever-changing situation with COVID-19. As the Delta variant continues to cause infection rates and hospitalizations to rise, we are monitoring work environments to make the teammate experience as engaging, productive and meaningful as possible. In June, we extended remote work through Labor Day for about 35% of teammates who are currently working remotely. The remaining 65% of remote teammates were informed they would not be returning on site and would work remotely for the long term. Due to the evolving situation with the Delta variant, we are further extending the current remote work situation for teammates working remotely. Announcements: Long-Term Remote Work · The current remote work situation is being extended through the end of 2021. This extension will allow teammates to plan for the change and for parents to make arrangements for their children to return to school and daycare with the least possible disruption. · Starting Monday, January 3, 2022, roughly 35% of teammates currently working remotely will return to on-site/office environments for all or part of their work hours. · If you are in the 35% of teammates identified to return to on-site work, you will continue to work remotely until January 2, 2022. · If your leader has informed you that you are working remote for the long term, your situation will not change. We will continue to update you if the situation changes, but for now, this extension is effective immediately. Reminders: · For guidance on expectations for remote teammates, please see Remote Work Policy. · Please do not move to another state of residence without consultation and permission from your leader and HR Strategic Business Partner, who will advise based on our Work Location Guidelines. · For the latest guidance on travel and meetings, please see the COVID-19 Travel Guidance Intranet page. · More information is available on the Remote Work page on the Intranet. Whether you have been working remotely or on-site, thank you for your commitment to Atrium Health as we continue to navigate the ever-changing waters of COVID-19. You truly live our mission to improve health, elevate hope and advance healing – for all.
CPM News
Congratulations to our CPM 2021 Wake Forest School of Medicine Award Recipients Timothy Howard, PhD – Established Investigator – Basic/Translational Award Kylie Kavanagh, VMS – Mid-Career Investigator – Basic/Translational Award Giselle Melendez, MD – Early Career Investigator – Clinical/Population Award Barbara Nicklas, PhD – Established Investigator – Clinical/Population Award Rebecca Wells, MD, MPH – Mid-Career Investigator - Clinical/Population Award
Announcements
2021 Walk to End Alzheimer’s – Saturday, Nov 6th Facts: Over 6 million people are living in the US with Alzheimer’s. One in 10 people age 65 and older will receive an Alzheimer’s diagnosis. Alzheimer’s and other dementia deaths have increased by 16% during the COVID pandemic. Every 65 seconds someone in the US develops the disease. Join the Sticht Center walking team and/or make a contribution towards the team’s fundraising goal http://act.alz.org/goto/StichtCenterTeam2021 This year’s Walk will be held at Bailey Park (575 N. Patterson Ave) Registration begins at 9 am with opening ceremonies starting at 10am and the Walk starting at 10:30 am. Walk co-Captains: Liz Chmelo & Deb Burcombe
Burroughs Wellcome Fund – Climate Change and Human Health Seed Grants The Burroughs Wellcome Fund aims to stimulate the growth of new connections between scholars working in largely disconnected fields who might together change the course of climate change’s impact on human health. Over the next two years, we will dedicate $1M to supporting small, early-stage grants of $2,500 - $50,000 toward achieving this goal. Due Date: December 15th Info Link: https://www.bwfund.org/funding-opportunities/climate-change-and-human-health/climate-change-and-human-health-seed-grants/
The Klingenstein-Simons Neuroscience Fellowship The Klingenstein-Simons Neuroscience Fellowship supports innovative research by early career investigators. The research should have relevance for understanding the mechanisms underlying any of a wide range of neurological and behavioral disorders, and it may lead to improvements in the diagnosis and treatment of these disorders. The Klingenstein-Simons Fellowship supports early-career investigators engaged in basic or clinical research that may lead to a better understanding of neurological and psychiatric disorders. Several areas within neuroscience are of particular interest: Cellular and molecular neuroscience. Studies of the mechanisms of neuronal excitability and development, and of the genetic basis of behavior. Neural systems. Studies of the integrative function of the nervous system. Translational research. Studies designed to improve our understanding of the causes, prevention, diagnosis, and treatment of neurological and psychiatric disorders. KSN will award $225,000 payable over a 3-year period beginning July 1, 2022. Can cover salary support, research assistants, equipment, or any other purpose which promotes the scientific activities of the KSN Fellow. Due Date: February 15, 2022 Info Link: https://klingenstein.org/esther-a-joseph-klingenstein-fund/neuroscience/applying/
Notice of Special Interest (NOSI): Leveraging Microbial Exposure for Improving Mouse Models of Human Immunity NOSI solicits research on immunologic characterization of mice with diverse microbial exposures (commonly referred to as “dirty mice”) to determine their usefulness as research tools to advance understanding of human immune function in homeostasis and in response to infectious or immune-mediated diseases. This NOSI aims to stimulate research proposing to characterize immune system development, regulation and function in dirty mice via: 1) comparison of (a) mouse line(s) housed in a “clean” environment with animals housed in a “dirty” facility during homeostasis or in various infectious or immune-mediated disease models; or 2) in vitro comparison of immune profiles in primary human cells and primary cells from dirty mice. These studies will advance our understanding of the impact of a host’s microbial exposure and experience on the development and maintenance of immunity and provide the necessary data to encourage broader use of dirty mouse models in immunologic studies. Due Date: February 16, 2022 FOA - https://grants.nih.gov/grants/guide/pa-files/PA-20-195.html Info Link: https://grants.nih.gov/grants/guide/notice-files/NOT-AI-21-072.html
Foundation Research Opportunities: https://ctsi.wakehealth.edu/-/media/WakeForest/CTSI/Files/Funding-Opportunities/NIH-Funding-Opportunities.pdf
NIH Research Opportunities: https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm
Upcoming Events
Center on Diabetes, Obesity, and Metabolism (CDOM) – Seminar Series Date/Time: Monday, November 1st (4 pm) Speaker: Matthew O’Brien, MD Associate Professor of Medicine (General Internal Medicine & Geriatrics) and Preventive Medicine (Epidemiology) Northwestern University, School of Medicine Title: “Health Equity in Diabetes Screening and Prevention: A Focus on Safety-Net Community Health Centers” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=mfa22f61e63ada080c8859bd5856c4c3e Meeting #: 1612 07 3479 Passcode: cdom
2021 William R. Hazzard, MD Translational Research in Aging Symposium – “Translational Perspectives on Energy and Aging” Friday, November 5th, 2021 – 9:30 am – 3:00 pm The Hazzard Symposium is an annual event at Wake Forest School of Medicine which features internationally-renowned speakers in gerontology and geriatric medicine with the purpose of translating discoveries in aging research to the care of older adults. The Keynote Speaker for the 2021 Hazzard Symposium is Pinchas Cohen, MD, Dean of the University of Southern California School of Gerontology. His Keynote address will be “Mitochondrial-derived peptides and their roles in Alzheimer’s Disease” Other external speakers include Edward Lesnefsky, MD (VCU), Anthony Molina, PhD (UCSD) and Dori Beeler, PhD (Atrium). We’ll also hear from several Wake Forest teammates: Dr. Kitzman, Dr. Pardee, Dr. Nicklas, Dr. Kramer and Dr. Mahapatra. Registration required: https://us02web.zoom.us/webinar/register/WN_d40KXyWvQDuMPaLxukHKxw
Molecular Medicine and Translational Science Graduate Program Seminar Series -MMTS 711 Date/Time: Friday, November 5th (11 am – 12 pm) Speaker(s): Brendan Johnson 3rd yr MMTS PhD Candidate (Mentor: Mark Cline, DVM, PhD – Pathology-Comparative Medicine) “Long-term Neurocognitive Outcomes of Total-body Irradiation in Rhesus Macaques” Lindsey Farris 3rd yr MMTS PhD Candidate (Mentor: Leslie Poole, PhD - Biochemistry) “Understanding and Overcoming Doxorubicin-Induced Cardiotoxicity via Mitochondrial Antioxidants” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=mf680befda8e59a5dba2b178b028b9e2c
Recent Publications
Rohde MM, Snyder CM, Sloop J, Solst SR, Donati GL, Spitz DR, Furdui CM, *Singh R. The mechanism of cell death induced by silver nanoparticles is distinct from silver cations. Part Fibre Toxicol. 2021 Oct 14;18(1):37. PMID: 34649580. https://doi.org/10.1186/s12989-021-00430-1
Aleem S, Walker LS, Hornik CD, Smith MJ, Grotegut CA, Weimer KED. Severe Congenital Syphilis in the Neonatal Intensive Care Unit: A Retrospective Case Series. Pediatr Infect Dis J. 2021 Oct 5. (Online ahead of print) PMID: 34620796. https://doi.org/10.1097/inf.0000000000003370
**Vemuri R, Sherrill C, Davis MA, Kavanagh K. Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):1906-1914. PMCID: PMC8514065. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8514065/
Kim TH, Young SL, Sasaki T, Deaton JL, Schammel DP, Palomino AWA, Jeong J-W, Lessey BA. Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium. J Clin Endocrinol Metab. 2021 Oct 19;dgab753. (Online ahead of print) PMID: 34665857. https://doi.org/10.1210/clinem/dgab753
Slingluff CL, Lewis KD, Andtbacka R, Hyngstrom J, Milhem M, Markovic SN, Gowles T, Hamid O, Hernandez-Aya L, Claveau J, Jang S, Philips P, Holtan SG, Shaheen MF, Curti B, Schmidt W, Butler MO, Paramo J, Lutzky J, Padmanabhan A, Thomas S, Milton D, Pecora A, Sato T, Hsueh E, Badarinath S, Keech J, Kalmadi S, Kumar P, Weber R, Levine E, Berger A, Bar A, Beck JT, Travers JB, Mihalcioiu C, Gastman B, Beitsch P, Rapisuwon S, Glaspy J, McCarron EC, Gupta V, Behl D, Blumenstein B, Peterkin JJ. Multicenter, double-blind, placebo-controlled trial of seviprotimut-L polyvalent melanoma vaccine in patients with post-resection melanoma at high risk of recurrence. J Immunother Cancer. 2021 Oct;9(10):e003272. PMCID: PMC8488725. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8488725/