Announcements

Foundation Funding Opportunities https://ctsi.wakehealth.edu/-/media/WakeForest/CTSI/Files/Funding-Opportunities/NIH-Funding-Opportunities.pdf   NIH Funding Opportunities https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm Pilot and other Funding Opportunities https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=51199f2348-EMAIL_CAMPAIGN_2021_1_11&utm_medium=email&utm_term=0_9d8dbeb58a-51199f2348-194798127

Upcoming Events

Center for Redox Biology and Medicine – WebEx Seminar Date/Time:     Tuesday, January 19th – 11am Speaker:         Dr. Peter Nagy, PhD                         Professor and Head of Department of Molecular Immunology and Toxicology                         National Institute of Oncology, Hungary     https://www.linkedin.com/in/peter-nagy-17b5a1a2/ Title:               “Reprogrammed Transsulfuration Promotes Basal Like Breast Tumor Progression via Realigning Cellular Cysteine-persulfidation” WebEx:           https://bit.ly/3scjoMx

Older Americans Independence Center (Pepper Center) Open House You are invited to an Open House sponsored by the Wake Forest Claude D. Pepper Older Americans Independence Center (aka Pepper Center) on Thursday, January 21st from 4pm – 5:30pm. Come learn about available resources:          Imaging support                      Biostatistics support And see how we can help advance                 Human research support       Pilot funding your research!                                        Basic science and biological assessments                                                                            Mentoring and Early Career Support RSVP (or questions): Laura B. Hayworth ( hayworth@wakehealth.edu )  713-8548

Recent Publications

Hazan S, Spradling-Reeves KD, Papoutsis A, Walker SJ. Shotgun Metagenomic Sequencing Identifies Dysbiosis in Triplet Sibling with Gastrointestinal Symptoms and ASD. Children (Basel). 2020 Nov 25;7(12);E255. PMID: 33255785. https://doi.org/10.3390/children7120255 

Dominijanni A, Devarasetty M, Soker S. Manipulating the Tumor Microenvironment in Tumor Oranoids Induces Phenotypic changes and Chemoresistance. iScience. 2020 Nov 23;23(12):101851. PMCID: PMC7724203. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7724203/ 

Hassan S, Pullikuth A, Nelson KC, Flores A, Karpova Y, Baiz D, Zhu S, Sui G, Huang Y, Choi YA, D’Agostino Jr RD, Hemal A, von Holzen U, Debinski W, Kulik G. b2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1. Mol Cancer Res. 2020 Dec;18(12):1839-1848. PMID:32928910. https://doi.org/10.1158/1541-7786.mcr-19-1037 

Kamimura D, Valle KA, Blackshear C, Mentz RJ, Yeboah J, Rodriguez CJ, Herrington DM, Suzuki T, Clark III D, Fox ER, Shah AM, Stacey RB, Hundley WF, Correa A, Butler J, Hall ME. Relation of Low Normal Left Ventricular Ejection Fraction to Heart Failure Hospitalization in Blacks (From the Jackson Heart Study). Am J Cardiol. 2020 Dec 1;136:100-106. PMID: 32910930. https://doi.org/10.1016/j.amjcard.2020.08.025 

Tavolara TE, Niazi MKK, Ginese M, Piedra-Mora C, Gatti DM, Beamer G, Gurcan MN. Automatic Discovery of Clinically Interpretable Imaging Biomarkers for Mycobacterium Tuberculosis Supersusceptibility Using Deep Learning. EBiomedicine. 2020 Dec;62:103094. PMCID: PMC7658666. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7658666/

Member News

Ellen Quillen, PhD and Katherine Cook, PhD are Co-I’s on a new grant with Bethany Kerr, PhD as PI.The grant title is “Profiling combinatorial treatment response in early and late bone metastatic breast cancer”The goal of the grant is to evaluate the effect of antiestrogen therapies in an estrogen-receptor positive breast cancer cell line to reduce bone metastasis, a major contributor to cancer mortality. Using both cellular and mouse models of bone metastasis, we will evaluate the metabolomic and gene expression changes in tumors and the bone microenvironment in response to combinatorial antiestrogen treatment. The ultimate goal of this work is to identify biomarkers of prognosis and treatment response to prevent bone metastasis in patients with breast cancer.

Member Highlights

J. Mark Cline, DVM, PhD Professor, Pathology – Comparative Medicine Dr. Mark Cline is a board-certified veterinary pathologist with >25 years of NIH-funded experience in the discovery and development of animal models of cancer. Much of his past work has focused on hormonal and dietary effects on breast and reproductive cancers, including studies in nonhuman primates (NHP), rodents, and translational work in human subjects. He is interested in developing cancer prevention and treatment studies by seeking out and studying spontaneous cancers in aging primates. Dr. Cline’s group also studies radiation effects in neoplastic and normal tissue, including radiation-induced neoplasms. He is the Principal Investigator for the NIAID Primate Radiation Survivor Core (U01 AI150578) funded through 2027, and PI of a DOD/CDMRP Focused Program designed to assess cardiac, metabolic, immune, and genomic injury in irradiated nonhuman primates; these two program-level grants focus on normal tissue injury by ionizing radiation including cancer outcomes. He has directed Wake Forest’s long-standing NIH post-DVM Comparative Medicine T32 institutional training grant for the past 12 years. Misc. recent papers: https://pubmed.ncbi.nlm.nih.gov/32942304/ https://pubmed.ncbi.nlm.nih.gov/31189721/