Announcements
The Prostate Cancer Foundation & Pfizer – Announce the PCF-Pfizer Health Equity Challenge Awards – RFP Due Dates: Letter of Intent (April 9, 2021) Full Proposals (August 30, 2021) *only accepted LOIs will be invited to submit full proposals The intent of the RFP is to support general research projects that will improve the understanding of or reduce disparities in diagnosis, management and outcomes of prostate cancer patients in minority and underserved communities. Clinical area – Oncology-Genitourinary-Prostate Cancer Grant amounts to range $100K - $150K For full information: https://res.cloudinary.com/pcf/image/upload/v1612973731/PCF_Health_Equities_Challenge_Awards_RFP-FINAL_2-10-21_exz5o0.pdf
WFSOM – COVID-19 Research Assistance Fund RFA The goal of these funds is to assist ongoing research teams that have been negatively impacted by the COVID-19 pandemic. This funding mechanism is open to all research types, ranging from fundamental basic science to population-based teams. Applications to support negatively impacted projects that are interdisciplinary, related to Academic Learning Health System, or focused on health equity research are encouraged Projects must clearly document 1) the impact of COVID-19 on the team’s ongoing research portfolio, and 2) how these funds will provide a catalyst for future success. $50,000 in direct costs. All funds to be spent within a 1-yr period. Full Application Deadline is May 2nd Full info: https://wakehealth.us18.list-manage.com/track/click?u=94c31ea49a1f4fdcae1168ad4&id=1a64689103&e=e983df7115&utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=a4c5711217-EMAIL_CAMPAIGN_2020_04_14_08_58_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-a4c5711217-
Foundation, Pilot, NIH, Misc. Funding Opportunities https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=8e38cce881
Upcoming Events
Comparative Medicine Date/Time: Tuesday, March 9th (3:30 pm – 4:30 pm) Speaker: Suzanne Danhauer, PhD Professor (Tenured) – PHS, Social Sciences & Health Policy Title: “Well-Being & Resilience in Academic Medicine (in a time of great uncertainty): Background, Resources, & Practical Strategies” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=mbf6a37ec3597a2cb088933a5f0d9a6fe Meeting #: 185 620 8949 Passcode: AbfP8XNkJ53
Phys/Pharm Virtual Seminar Series Date/Time: Wednesday, March 10th (4 pm – 5 pm) Speaker: Daniel Castro, PhD Acting Instructor – Postdoc Depts. of Anesthesiology & Pharmacology University of Washington Title: “Nucleus Accumbens Medial Shell Mediates Distinct Aspects of Reward and Motivation” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=me0f12b23b8f166c344198778a46c74c7 Meeting #: 171 316 1571 Passcode: mvSftNaj252
Molecular Medicine Journal Club – MMTS 782 Date/Time: Friday, March 12th (10:00 am – 11:00 am) Speaker: Rabina Mainali (PhD student – Dept. of Physiology & Pharmacology) Title: “Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity” Tur, J et al., 2020, Cell Reports 32, 108079 https://doi.org/10.1016/j.celrep.2020.108079 Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m78492e974abffa3b36c84066419a8ff Meeting #: 178 672 2875 Passcode: mDNXWbPm539
Recent Publications
*Frye BM, Valure PM, Craft S, Baxter MG, Scott C, Wise-Walden S, Bissinger DW, Register HM, Copeland C, Jorgensen MJ, Justice JN, Kritchevsky SB, Register TC, Shively CA. Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus). Geroscience. 2021 Feb 21 [Online ahead of print] PMID: 33611720. https://doi.org/10.1007/s11357-021-00338-w
Acosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Admission Hemoglobin Levels are Associated with Functional Outcome in Spontaneous Intracerebral Hemorrhage. Crit Care Med. 2021 Feb 15. [Online ahead of print] PMID: 33591003. https://doi.org/10.1097/ccm.0000000000004891
Baechle JJ, Smith PM, Solorzano CC, Tran TB, Postlewait LM, Maithel SK, Prescott J, Pawlik T, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Shirley LA, Fields RC, Jin L, Abbott DE, Ronnekleiv-Kelly S, Sicklick JK, Yopp A, Mansour J, D Q-Y, Seiser N, Votanopoulos K, Levine EA, Poultsides G, Kiernan CM. Cumulative GRAS Score as a Predictor of Survival after Resection for Adrenocortical Carcinoma; Analysis from the U.S. Adrenocortical Carcinoma Database. Ann Surg Oncol. 2021 Feb 14. [Online ahead of print] PMID: 33586069. https://doi.org/10.1245/s10434-020-09562-8
Schulson L, Lin M-Y, Paasche-Orlow MK, Hanchate AD. Limited English Proficient patient Visits and Emergency Department Admission Rates for Ambulatory Care Sensitive Conditions in California: A Retrospective Cohort Study. J Gen Intern Med. 2021 Feb 2. [Online ahead of print] PMID: 33528781. https://doi.org/10.1007/s11606-020-06523-5
Yoo KM, Murphy SV, *Skardal A. A Rapid Crosslinkable Maleimide-Modified Hyaluronic Acid and Gelatin Hydrogel Delivery System for Regenerative Applications. Gels. 2021 Feb 1;7(1):13. PMID: 33535669. https://doi.org/10.3390/gels7010013
Member News
Congratulations to Dr. Xuewei Zhu on the funding of her CVSC Pilot Award Project title: “PUFA desaturation, NAD+ metabolism, and macrophage NLRP3 inflammasome” Dr. Cristina Furdui is Co-I on the project.
Congratulations to Dr. Kylie Kavanagh on the funding of her DOD and pilot grant awards. DOD grant: “Advancement of CRISPR-based Adipose Therapeutics for Type 2 Diabetes in Non-human Primates” Pilot grant: “Effect of Genotype on the Response of Inflammatory Markers to Dietary Inosine”
Member Highlights
Sarah Cilvik, MD, PhD Assistant Professor, Pediatrics – Neonatology Dr. Sarah Cilvik is a clinical neonatologist with an interest in studying the developmental origins of cardiovascular disease in a nonhuman primate model. She completed her MD and PhD (Developmental Biology) as part of the Medical Scientist Training Program at Washington University in St. Louis while studying the role of fibroblast growth factors in postnatal cardiac remodeling in a mouse model. She then moved on to residency in Pediatrics at the University of Utah, followed by fellowship in Neonatal-Perinatal Medicine at the University of Colorado. There she studied fetal physiology in a late preterm pregnant sheep model, examining the role that elevated fetal glucagon plays in fetal metabolism and nutritional status, in addition to placental function. At the completion of her fellowship in 2020, she accepted a position as Assistant Professor in Pediatrics-Neonatology at Wake Forest and is now working to establish a perinatal/pregnancy model in the Wake Forest Vervet Research colony to study long-term cardiovascular outcomes in the offspring from pregnancies with adverse intrauterine environments. Recent publications: Koo HY, El-Baz LM, House S, Sarah N Cilvik, Dorry SJ, Shoukry NM, Salem ML, Hafez HS, Dulin NO, Ornitz DM, Guzy RD. Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. J Pathol. 2018 Sep;246(1):54-66. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6175645/
Sarah N. Clivik, Wang JI, Lavine KJ, Uchida K, Castro A, Gierasch GM, Weinheimer CJ, House SL, Kovacs a, Nichols CG, Ornitz DM. Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PloS One. 2013 Dec 11;8(12):e82979. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3859602/