Point of Information
Upcoming Changes to the Biographical Sketch and Other Support Documents on projects with due dates on/after May 25, 2021 Info Link on changes - https://grants.nih.gov/grants/guide/notice-files/NOT-OD-21-073.html If you have specific questions please contact the Office of Sponsored Programs If you need samples and blank formats please contact Ginger Pate ( grpate@wakehealth.edu )
Announcements
Notice of Special Interest (NOSI): Administrative Supplement for Genome-side Genotyping of Existing Samples from Minority Racial/Ethnic Populations and Sharing of Associated Epidemiologic Data (NOT-CA-21-041) https://grants.nih.gov/grants/guide/notice-files/NOT-CA-21-041.html National Cancer Institute (NCI) seeks to leverage existing biospecimens to increase the representation of racial/ethnic minority individuals in germline genome-wide data repositories with accompanying exposure, phenotype, and outcome data. Funds obtained through these administrative supplements should be used for processing existing samples and analyzing and managing the derived data from understudied racial/ethnic populations studies. These studies will also need to successfully compete for germline genome-wide genotyping services offered by the NIH Center for Inherited Disease Research (CIDR) program through a companion application to PAR-20-230 (Instructions for a CIDR submission for this initiative are found on this page). Data from this NOSI initiative are expected to be broadly shared with the extramural research community. Budgets should not exceed $150,000 in total costs. Due by May 20,2021
Notice of Special Interest (NOSI): Integrative Omics Analysis of NHLBI TOPMed Data (NOT-HL-21-007) no clinical trials https://grants.nih.gov/grants/guide/notice-files/NOT-HL-21-007.html NHLBI seeks to fund analyses and tool development that utilize existing TOPMed omics data to uncover the molecular mechanisms driving HLBS disease. Investigators are encouraged to utilize a systems approach incorporating computational modeling to bring together high throughput genotype and phenotype datasets. Analyese may incorporate new or existing data generated outside of TOPMed. However, this notice seeks studies that will use existing TOPMed data as the major resource for analysis of HLBS disease and measures. Applications due on or after June 5, 2021
Notice of Special Interest: Impact of COVID-19 on Dementia Risk, Progression and Outcomes in ADRD Populations (NOT-NS-21-037) https://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-037.html NINDS is interested in applications for supplements to human subjects awards administered by the NINDS to conduct research on the effects of COVID-19 on the development of, or disease progression in, Alzheimer’s Disease-Related Dementias (ADRDs). Investigators who are currently researching ADRD or at-risk for ADRD populations are encouraged to apply for additional support to examine the impact of COVID-19 in an area of research topics. (see info link for detailed topics) Applications due by May 5, 2021
NIH Funding Opportunities https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm
Foundation Funding Opportunities https://ctsi.wakehealth.edu/-/media/WakeForest/CTSI/Files/Funding-Opportunities/NIH-Funding-Opportunities.pdf
Additional Funding Opportunities https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=f1958df513-EMAIL_CAMPAIGN_2021_3_15&utm_medium=email&utm_term=0_9d8dbeb58a-f1958df513-194798127
Upcoming Events
Department of Biochemistry Student Seminar Date/Time: Tuesday, March 23rd (12 pm – 1 pm) Speaker: Steven Moran - Graduate Student – Dept. Biochemistry & Molecular Biology Title: “The Role of Cytoskeletal Elements in Vesicular Stomatitis Virus Ribonucleoprotein Motion and Distribution in the Cytoplasm of Host Cells” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m6c6c92796c0723c67aa4a20d64c88d4a Meeting #: 185 641 6738 Passcode: bVPAbumm289
The BTCOE/NRO Program presents: Date/Time: Tuesday, March 23rd (3:30 pm – 4:30 pm) Speaker: Metin Gurcan, PhD (Director – Center for Biomedical Informatics & Professor – Internal Medicine) Title: “Quantitative Image Analysis and Artificial Intelligence for Brain Tumors” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m9a1ee4ab9906fed13c50c2668e5bdb42 Meeting #: 185 454 5623 Passcode: sZeMGD3PF43
Comparative Medicine Research Strategy Meeting Date/Time: Tuesday, March 23rd (3 pm – 4 pm) Speaker: Matt Quinn, PhD (Assistant Professor, Pathology – Comparative Medicine) Title: “NIA U01: A Humanized Monoclonal FSH Blocking Antibody for Alzheimer’s Disease” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m904738bbec2735e8cfcb9db614dd68a7 Meeting #: 185 900 8190 Passcode: 5cEmfdQ2e7f
Biochemistry/Microbiology & Immunology Virtual Seminar Date/Time: Thursday, March 25th (2 pm – 3 pm) Speaker; Dr. Breann Brown Assistant Professor, Dept. of Biochemistry – Vanderbilt University School of Medicine Lab & bio link: https://lab.vanderbilt.edu/brown-lab/ Title: “Control of Protein Function by Assembly: Implications for Combating Stress and Disease” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m4ca2661c04609dca3112ef2127b4e442 [wakehealth.webex.com] Meeting #: 178 372 8612 Passcode: Wake21
Molecular Medicine Journal Club – MMTS 782 Date/Time: Friday, Mar 26th (10 am – 11 am) Speaker: Ashlynn Brock (Master’s student – Biomedical Science; Research Assoc. – Molecular Medicine Lab) Title: “Brown adipose tissue is associated with cardiometabolic health” Link to paper: https://wakehealth.sharepoint.com/sites/MolecularMedicineResearch/Journal%20Articles/Forms/2019.aspx?viewid=fb520096%2D254c%2D457f%2Da8da%2D6c57a9dfb122&id=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles%2FJournal%20Club%203%2026%2021%2Epdf&parent=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m78492e974abffa3b36c84066419a8ff Meeting #: 178 672 2875 Password: mDNXWbPm539
Recent Publications
*Zimmerman KD, Espeland MA, Langefeld CD. A practical solution to pseudoreplication bias in single-cell studies. Nat Commun. 2021 Feb 2;12(1):738. PMCID: PMC7854630. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7854630/
Rejeski JJ, Fanning J, Nicklas BJ, Rejeski WJ. Six-month changes in ghrelin and glucagon-like peptide-1 with weight loss are unrelated to long-term weight regain in obese older adults. Int J Obes (Lond). 2021 Feb 1. [Online ahead of print] PMID: 33526855. https://doi.org/10.1038/s41366-021-00754-0
Fortis S, Cornelias A, Bhatt SP, Hoffman EA, Han MK, Bhakta NR, Paine 3rd R, Ronish B, Kanner RE, Dransfield M, Hoesterey D, Buhr RG, Barr RG, Dolezal B, Ortega VE, et. al. Ratio of Forced Expiratory Volume in 1 second/Slow Vital Capacity (FEV1/SVC)<0.7 is associated with clinical, functional, and radiologic features of obstructive lung disease in smokers with preserved lung function. Chest. 2021 Feb 1;S0012-3692(21)00229-4. [Online ahead of print] PMID: 33539837. https://doi.org/10.1016/j.chest.2021.01.067
Klann JG, Weber GM, Estiri H, Moal B, Avillach P, Hong C, Castro V, Maulhardt T, Tan ALM, Geva A, Beaulieu-Jones BK, malovini A, South AM, et, al. Validation of an Internationally Derived Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data. J AM Med Inform Assoc. 2021 Feb 10;ocab018. [Online ahead of print] PMID: 33566082. https://doi.org/10.1093/jamia/ocab018
*Miller B, Mainali R, *Nagpal R, Yadav H. A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome-Intestine-Pancreas Axis. Int J Mol Sci. 2021 Feb 6;22(4):1647. PMID: 33562070. https://doi.org/10.3390/ijms22041647
Member News
Congratulations to Dr. Greg Hawkins on the birth of his newest granddaughter. Emerson “Emma” Lei Suriano 5 lbs 1 oz Born March 6th
Congratulations to Dr. Kim Keeves (CPM) and Dr. Mindy Sampson (Atrium) For their newly funded Atruim/WFSM collaborative pilot study. Title: “A Pilot Study: A Comprehensive Analysis of SARS-CoV-2 Strains and Microbes in Healthcare Workers with COVID-19 Reinfections” Co-I’s include: Catherine Passaretti, MD (Atrium) Christopher Polk, MD (Atrium) Jennifer Priem, PhD, MA (Atrium) Kristin Fischer, MHA (Atrium) Laura Cox, PhD (CPM) Werner Bischoff, MD (WFSOM)
CPM Faculty Member Highlights
Metin N. Gurcan, PhD Director of the Center for Biomedical Informatics Director of Clinical Image Analysis Lab Informatics Program Leader of the Wake Forest CTSI Professor of Internal Medicine, Pathology and Biomedical Engineering Dr Gurcan received his BSc and PhD degrees in electrical and electronics engineering from Gilkent University, Turkey, and his MSc degree in digital systems engineering from the University of Manchester Institute of Science and Technology, England. After completing his post-doctoral studies in the department of radiology at the University of Michigan, he worked as a senior researcher and a product director at a high-tech company, specializing in computer-aided detection and diagnosis of cancer from radiological images. Previously, he was a professor of biomedical informatics and pathology and director of the Division of Clinical and Translational Informatics at the Ohio State University. Research Interests: Dr. Gurcan is an internationally recognized researcher and educator in the fields of medical image analysis, artificial intelligence, and biomedical informatics. His research has been supported by NIH, NCATS, NCI, NIDCD, NHLBI, NBIB, NIAID, DOD, as well as awards from several nonprofit organizations. Inventions: Dr. Gurcan was awarded three patents for inventions in medical image analysis. Two companies were formed in the US based on his inventions. Publications, Awards, and Service: Dr. Gurcan has authored more than 200 peer-reviewed publications and book chapters. He has received several awards, including the British Foreign and Commonwealth Organization, NCI caBIG Embodying the Vision, Children’s Neuroblastoma Cancer Foundation Young Investigator, NIH EUREKA, and OSU CCC Pelotonia Idea. Dr. Gurcan is a Fellow of SPIE and a senior member of IEEE and AMIA. He currently serves on the editorial boards of Journal of Pathology Informatics and Journal of Medical Imaging, has organized and chaired the Histopathological Image Analysis workshop in the last 14 years, and chairs the SPIE Medical Imaging Symposium 2021. Links: https://school.wakehealth.edu/Research/Institutes-and-Centers/Center-for-Biomedical-Informatics http://tsi.wakehealth.edu/CIALab/ https://www.wakeforestinnovations.com/experts/metin-gurcan-phd/