Announcements
Critical Illness, Injury, and Recovery Research Center (CIIRRC) Request for Applications for Pilot Awards CIIRRC seeks innovative interdisciplinary applications for clinical, and translational pilot research projects related to critical illness and injury. Existing or newly formed inter-disciplinary teams are encouraged to apply. Pilots should address key issues within acute and critical care environments that can be rapidly implemented to generate actionable data related to CIIRRC’s mission. Priority this cycle will be placed on pilots with one or more of the following features: 1) a streamlined plan for execution, including those that add to existing projects 2) focus on rural/remote communities 3) racial/ethnic health disparities 4) new collaborative projects with Atrium Health. $9,000 total for six-month project period Due: April 16th Full Info: https://wakehealth.us18.list-manage.com/track/click?u=94c31ea49a1f4fdcae1168ad4&id=b777618f84&e=e983df7115
Whitehall Foundation Applications Requested The Foundation is currently interested in basic research in neurobiology, defined as follows: Invertebrate and vertebrate (excluding clinical) neurobiology, specifically investigations of neural mechanism involved in sensory, motor, and other complex functions of the whole organism as these relate to behavior. The overall goal should be to better understand behavioral output or brain mechanisms of behavior. The Foundation emphasizes the support of young scientists at the beginning of their careers and productive senior scientists who wish to move into new fields of interest. Grants up to 3 years with a possible renewal of max of 2 years is possible. Funding ranges between $30K- $75K per year. Full info: http://www.whitehall.org/grants/
2021 Allen Distinguished Investigator (ADI) Open Calls Up to 11 awards will be made for up to $16.5M total funding to support pioneering research in Micropeptides Neural Circuit Design Mammalian Synthetic Development Letters of Intent are due by April 15th for the three initiatives. Selected LOIs will be invited to submit full proposals. Full Info: https://alleninstitute.org/2021-adi-open-calls/?utm_source=Newsletter&utm_medium=email&utm_campaign=FrontMarNews21&utm_content=OpenCalls
Alex Lemonade Stand Foundation is Sponsoring the 2021 Crazy 8 Initiative Awards Priority will be given to projects involving innovative studies of high-grade gliomas, nonmedulloblastoma embryonal brain tumors, non-Ewing Sarcoma fusion-positive sarcomas, fusion-negative sarcomas, big data and/or catalyzing clinical trials. Investigators with proposals focusing on leukemias, neuroblastoma, Ewing sarcoma and medulloblastoma are welcome to apply. $6.5M is allocated for funding this second round of initiatives. Proposals will be judged on innovation, scientific soundness, significance and the potential for impact on improving the lives of children with cancer. Due Dates: Letter of Intent due April 26th Full proposal due August 5th (by invitation only) Virtual presentation due December 8-10 by finalists to ALSF leadership and the Crazy 8 Scientific Advisory Board to choose award recipient Full info: https://www.alexslemonade.org/sites/default/files/images/2020/crazy_8_rfa_2021_3.3.21.pdf
PAR-21-167: Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial not allowed) FOA encourages innovative research to develop, characterize, and improve animal models, biological materials, and novel technologies to better understand human health and disease. FOA seeks projects aimed at improving the diagnosis and control of diseases that interfere with animal use for biomedical research The proposed project must have broad application to multiple NIH Institutes or Centers and must explore multiple body systems or evaluate diseases that impact multiple body systems. Earliest submission date: May 16th No more than $200,000 in direct costs may be requested in a single year. The combined budget may not exceed $275K in direct costs for the 2 year project period. Full info: https://grants.nih.gov/grants/guide/pa-files/PAR-21-167.html?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=6f7bd5c664-EMAIL_CAMPAIGN_2020_04_14_08_58_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-6f7bd5c664-194798043
NIH Funding Opportunities https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm
Foundation Funding Opportunities https://ctsi.wakehealth.edu/-/media/WakeForest/CTSI/Files/Funding-Opportunities/NIH-Funding-Opportunities.pdf
Upcoming Events
CPM Virtual Seminar Series Date/Time: Thursday, April 1st (10:00 am – 11:00 am) Speaker: SChia-Chi Chuang Key, PhD Assistant Professor – Molecular Medicine, WFSOM Title: “ New Players in Cellular Lipid Accumulation” Zoom Link: https://zoom.us/j/2887710765?pwd=YlJpbDUvZWlsWTlvN2RVbGVzSmxiZz09 Meeting #: 288 771 0765 Passcode: CPM2021
Department of Biochemistry Student Seminar Date/Time: Tuesday, March 30th (1:00 pm – 2:00 pm) Speaker: Emily Martin (Graduate Student – Biochemistry & Molecular Biology) Title: “Investigating the mechanisms of hormone induced ROS that drives Arabidopsis root development” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m86f0c7c33e61c830d00acfaa16e7bce6 Meeting #: 185 083 0158 Passcode: B4GfxfidW62
Comparative Medicine Research Strategy Meeting Date/Time: Tuesday, March 30th (3:30 pm – 4:30 pm) Speaker 1: Greg Dugan, DVM – [Assistant Professor, Pathology-WFSOM] “General Overview of the Wake Forest Radiation Survivor Cohort”
Speaker 2: David Caudell, DVM, PhD – [Associate Professor, Pathology-WFSOM] “Thymic Recovery in a Pediatric Model of Radiation Injury”
Speaker 3: Mark Cline, DVM, PhD –[Professor, Pathology-WFSOM] “Development of the Pseudo-Pelger-Huet Anomaly as a Radiation Biomarker” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m0de4a6443424d7ff2b3cb7f61ed0fac6 Meeting #: 185 966 1988 Passcode: mHp5KzPkK93
Recent Publications
Clougherty JE, Kinnee EJ, Cardet JC, Mauger D, Bacharier L, Beigelman A, Blake KV, Cabana MD, Castro M, Chmiel JF, Covar R, Fitzpatrick A, Gaffin JM, Gentile D, Israel E, Jackson DJ, Kraft M, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lemanske Jr RF, Lima J, Martinez FD, Morgan W, Moy J, Myers R, Naureckas ET, Ortega VE, et, al. Geography, generalizability, and susceptibility in clinical trials. 2021 Feb 1;S2213-2600(21)00046-1. [Online ahead of print] PMID: 33539731. https://doi.org/10.1016/s2213-2600(21)00046-1
*Ruggiero AD, Key CCC, Kavanagh K. Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity. Front Nutr. 2021 Feb 17;8:625331. PMCID: PMC7925825. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7925825/
Miller RM, Beavers DP, Cawthon PM, Crotts C, Fanning J, Gerosa J, Greene KA, Hsieh KL, Kiel J, Lawrence E, Lenchik L, Lynch SD, Nesbit BA, Nicklas BJ, Weaver AA, Beavers KM. Incorporating nutrition, vests, education, and strength training (INVEST) in bone health: Trial design and methods. Contemp Clin Trials. 2021 Feb 22;106326. [Online ahead of print] PMID: 33631359. https://doi.org/10.1016/j.cct.2021.106326
Weber GM, Houng C, Palmer NP, Avillach P, Murphy SN, Gutierrez-Sacristan A, Xia Z, Serret-larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann KG, South AM, et, al. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study. medRxiv. 2021 Feb 5;2020.12.16.20247684. (Preprint) PMCID: PMC7872369. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7872369/
Wilson KE, Michaud TL, Almeida FA, Schwab RJ, Porter GC, Aquilina KH, Brito FA, Golden CA, Dressler EV, Kittel CA, Harvin LN, Boggs AE, Katula JA, Estabrooks PA. Using a population health management approach to enroll participants in a diabetes prevention trial: reach outcomes from the PREDICTS randomized clinical trial. Transl Behav Med. 2021 Mar 2;ibab010. [Online ahead of print] PMID: 33677529. https://doi.org/10.1093/tbm/ibab010
CPM Faculty Member Highlights
Matthew J. Jorgensen, PhD Associate Professor, Pathology – Comparative Medicine Dr Jorgensen received his undergraduate degree from the University of Massachusetts, where he first worked with nonhuman primates. He received his master’s and doctoral degree in comparative psychology from the University of California at Riverside. He completed research fellowships at Harvard Medical School’s New England Regional Primate Research Center and UCLA investigating self-injurious behavior in macaques and the effects of methamphetamine use on brain neurotoxicity and behavior in vervet monkeys. He worked at UCLA for seven years managing the NIH-supported nonhuman primate breeding colony, a biomedical resource used for multi-categorical research. In 2008 he joined WFSOM pathology/comparative medicine faculty when the grant and colony were transferred to the institution. Dr. Jorgensen manages and facilitates intramural and extramural studies utilizing a breeding colony of more than 300 vervet/African green monkeys. The colony operates as a national resource for primate-related research studies focused on diseased and prevention and therapy. Dr. Jorgenson facilitates numerous studies in immunology and vaccine development, diabetes and metabolism, and developmental brain imaging. He has recent industry partnerships exploring the efficacy of a respiratory syncytial virus (RSV) vaccine in adult African green monkeys and drug development for diabetes. He also studies the effectiveness of a novel surgical anesthetic compound using neonatal nonhuman primate models. Selected publications: Petropoulou P-I, Mosialou I, Shikhel S, Hao L, Panitsas K, Bisikirska B, Luo N, Bahna F, Kim J, Carberry P, Zanderigo F, Simpson N, Bakalian M, Kassir S, Shapiro L, Underwood MD, May CM, Soligapuram Sai KK, Jorgensen MJ, et.al. Lipocalin-2 is an anorexigenic signal in primates. Elife. 2020 Nov 24;9:e58949. PMCID: PMC7685704. https://pubmed.ncbi.nlm.nih.gov/33231171/ Takemura H, Palomero-Gallagher N, Axer M, Gräßel, Jorgensen MJ, Woods R, Zilles K. Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system. Elife. 2020 Aug 26;9:e55444. PMCID: PMC7532002. https://pubmed.ncbi.nlm.nih.gov/32844747/ Plant M, Armstrong C, Ruggiero A, Sherrill C, Uberseder B, Jefferies R, Nevarez J, Jorgensen MJ, Kavanagh K, Quinn MA. Advanced maternal age impacts physiologic adaptations to pregnancy in vervet monkeys. Geroscience. 2020 Dec;42(6):1649-1661. PMCID: PMC7732933. https://pubmed.ncbi.nlm.nih.gov/32588342/ Schmitt CA, Bergey CM, Jasinska AJ, Ramensky V, Burt F, Svardal H, Jorgensen MJ, Freimer NB, Grobler JP, Turner TR. ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies. PloS One. 2020 Jun 23;15(6):e0235106. PMCID: PMC7310727. https://pubmed.ncbi.nlm.nih.gov/32574196/ Kulis MD, Smeekens JM, Kavanagh K, Jorgensen MJ. Peanut applied to the skin of nonhuman primates induces antigen-specific IgG but not IgE. Immun Inflamm Dis. 2020 Jun;8(2):211-215. PMCID: PMC7212195. https://pubmed.ncbi.nlm.nih.gov/32220059/ Clemens E, Angeletti D, Holbrook BC, Kanekiyo M, Jorgensen MJ, Graham BS, Yewdell J, Alexander-Miller MA. Influenza-infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem. JCI Insight. 2020 Mar 12;5(5):e135449. PMCID: PMC7141390. https://pubmed.ncbi.nlm.nih.gov/32078584/