Announcements

North Carolina Diabetes Research Center (NCDRC) Pilot Grants – RFA 2022    This Pilot and Feasibility (P&F) program is designed to encourage and facilitate novel basic, clinical and translational research. Projects must demonstrate a clear path to subsequent grant support, translation to clinical programs, new company formation, licensing, not-for-profit partnering, or other channels. Projects must have a clear diabetes focus. Collaborative projects with investigators from other NCDRC institutions will be given priority for funding, as will proposals that make meaningful use of one of the following Core facilities: Duke Metabolomics(david.d’alessio@duke.edu) WF Proteomics/Genomics (molivier@wakehealth.edu) UNC Advanced Clinical Studies Methods(john_buse@med.unc.edu) WF Novel Animal Models (kkavanag@wakehealth.edu)    These pilot grant awards are not meant as bridge funding or as supplementary funding for existing projects.    LOI Due: August 25th    Up to 3 projects to be funded and receive up to $50,000 in direct costs per year for one year.    Full information: NCDRC Pilot RFA

Microbial Pathogenesis in Alzheimer’s Disease Grant          Intriguing evidence suggests Alzheimer’s disease may have a link to infectious diseases or a microbial mechanism. Could this be the missing link to lead to a cure for Alzheimer’s disease? To advance research that could shed light, and provide hope to the more than 5.7 Americans and 47 million people worldwide living with the disease, the IDSA Foundation established the Alzheimer’s Research Grant now known as the Microbial Pathogenesis in Alzheimer’s Disease Grant, in 2018 to foster further investigation.          These grants support research that suggest evidence of an infectious agent or microbial community is correlated to Alzheimer’s disease and promotes novel research in the field of microbial triggers for Alzheimer’s disease.          Applications due: August 31, 2021          Awards ranging between $30,000 - $250,000          Full information: https://idsaf.smapply.io/prog/2021ALZ/

Foundation Opportunities file:///C:/Users/grpate/Downloads/NIH%20Funding%20Opportunities%20(41).pdf  

NIH Funding Opportunities https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=085f8f4f29-  

Upcoming Events

Cancer Biology Seminar Date/Time:    Tuesday, July 13th  (9 – 10 am) Speaker:         Ravindra Deshpande, PhD (Postdoc) Title:               “LncRNA IPW inhibits growth of ductal carcinoma in situ by downregulating ID2 through miR29c.” Webex:           https://wakehealth.webex.com/wakehealth/j.php?MTID=mcfbbdf13b274693d58ae7eebe8cb0e19 [wakehealth.webex.com]

OAIC National Coordinating Center Early Career Faculty Working Group Webinar – “Understanding the Basics of the Grant Process” The goal of this webinar is to provide insights for early career stage faculty with information on preparing your grant application, identifying the most appropriate study section, and post-review steps. Date/Time:     Wednesday, July 14th (2:00 – 3:30pm) Presenters:     Rene Etcheberrigary, MD - Sr. Scientific Advisor Division of Extramural Activates (DEA) National Institute on Aging Kenneth Santora, PhD – Director Division of Extramural Activities (DEA) National Institute on Aging Registration required: https://us02web.zoom.us/webinar/register/WN_pgTBEMxoR0G6APaid1j85A

Alzheimer’s Research Symposium – “Innovations in Therapeutic Trials, Assessment & Care for Alzheimer’s Disease” Date/Time:     Wednesday, July 14th (4:30 – 6:00pm) List of speakers and full info: https://ctsi.wakehealth.edu/About-CTSI/Calendar?trumbaEmbed=view%3Devent%26eventid%3D152651669&utm Webex:           https://wakehealth.webex.com/wakehealth/j.php?MTID=md03d50cb614d7a2d48c1bc141120d91d Meeting #: 1616 66 8371 Passcode: HqGKNGen626

Recent Publications

Pan X-F, Yang JJ, Shu X-O, Moore SC, Palmer ND, Guasch-Ferre M, Herrington DM, Harada S, Eliassen H, Wang TJ, Gerszten RE, Albanes D, Tzoulaki I, Karaman K, Elliott P, Zhu H, Wagenknecht LE, Zheng W, Cai H, Cai Q, Matthews CE, Menni C, Meyer KA, Lipworth LP, Ose J, Fornage M, Ulrich CM, Yu D. Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis. Am J Clin Nutr. 2021 May 21;nqab152. (Online ahead of print). PMID: 34020444. https://doi.org/10.1093/ajcn/nqab152  

Cappuccio G, Berti CC, Baruffini E, Sullivan J, Shashi V, Jewett T, *Stamper T, Maitz S, Canonico F, Revah-Politi, Kupchik GS, Anyane-Yeboa K, Aggarwal V, Benneche A, Bratland E, Berland S, D’Arco F, Alves CA, Vanderver A, Longo D, Bertini E, Torella A, Nigro V, Telethon Undiagnosed Diseases Program; D’Amico A, van der Knaap MS, Goffrini P, Brunetti-Pierri N. Bi-allelic KARS1 pathogenic variants affecting functions of cytosolic and mitochondrial isoforms are associated with a progressive and multisystem disease. Hum Mutat. 2021 Jun;42(6):745-761. PMID: 33942428. https://doi.org/10.1002/humu.24210  

Woo H, Brigham EP, Allbright K, Ejike C, Galiatsatos P, Jones MR, Oates GR, Krishnan JA, Cooper CB, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner G, Barr RG, Martinez FJ, Han MK, Ortega VE, Parekh TM, Christenson S, Belz D, Raju S, Gassett A, Paulin LM, Putcha N, Kaufman JD, Hansel NN. Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of COPD. Am J Respir Crit Care Med. 2021 May 10 [Online ahead of print]. PMID: 33971109. https://doi.org/10.1164/rccm.202009-3721oc  

Rahbar E, Cotton BA, Wade CE, Cardenas JC. Acquired antithrombin deficiency is a risk factor for venous thromboembolism after major trauma. Thromb Res. 2021 Aug;204:9-12. (Epub 2021 May 28). PMID: 34091120. https://doi.org/10.1016/j.thromres.2021.05.015  

Reynolds LM, Zamora C, Lee UJ, Stokes AC, Benjamin EJ, Bhatnagar A, Payne TJ, Rodriguez CJ. Tobacco Use Prevalence and Transitions from 2013 to 2018 Among Adults with a History of Cardiovascular Disease. J Am Heart Assoc. 2021 Jun 15;10(12):e021118. PMID: 34102851. https://doi.org/10.1161/jaha.121.021118

Members NEWS

Dr. Xuewei Zhu has recently been named the Dolph O. Adams Awardee by the Society for Leukocyte Biology (SLB). The annual award is to recognize excellence of an investigator working in the area of cellular and molecular mechanisms of host defense and inflammation. This award is named in honor of the outstanding macrophage researcher Dolph O. Adams, MD, PhD and is given out to a junior/mid-career faculty or equivalent investigator. As the Adams Awardee, Dr. Zhu will present her exciting work on the role of ER membrane-anchored G6P transporter SLC37A2 in macrophage inflammation and metabolic homeostasis on July 29 during the Immunometabolism section II of the 2021 SLB meeting.