Announcements
WFSOM – The Academic Core of Atrium Health – Request for Applications COVID-19 Pilot Research Projects This pilot mechanism is open to all research types, ranging from fundamental basic science to population-based projects. Projects focused on understanding biological risk factors and optimal treatment for under-served populations or which address the specific COVID-19 related needs of our clinical population will be prioritized. Up to $50,000 in direct costs. Funding Cycle 1: February 1st Wake Forest Contact: Lindsay Trost ltrost@wakehealth.edu Full info link: https://wakehealth.us18.list-manage.com/track/click?u=94c31ea49a1f4fdcae1168ad4&id=1a64689103&e=e983df7115&utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=a4c5711217-EMAIL_CAMPAIGN_2020_04_14_08_58_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-a4c5711217-
WFSOM – The Academic Core of Atrium Health – Request for Applications COVID-19 Research Assistance Fund The goal of this funding is to assist ongoing research teams that have been negatively impacted by the COVID-19 pandemic. This mechanism is open to all research types ranging from fundamental basic science to population-based projects. Applications to support negatively impacted projects that are interdisciplinary, related to the Academic Learning Health System, or focused on health equity research are encouraged. Up to $50,000 in direct costs. All funds to be spent in a 1-year period. Funding Cycle 1: February 1st Wake Forest Contact: Lindsay Trost ltrost@wakehealth.edu Full info link: https://wakehealth.us18.list-manage.com/track/click?u=94c31ea49a1f4fdcae1168ad4&id=a9255167f9&e=e983df7115&utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=a4c5711217-EMAIL_CAMPAIGN_2020_04_14_08_58_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-a4c5711217-
Foundation, NIH, Internal Funding Opportunities https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=dfe5ced48a-EMAIL_CAMPAIGN_2021_1_18&utm_medium=email&utm_term=0_9d8dbeb58a-dfe5ced48a-194798127
Upcoming Events
InterAC Open Forum Date/Time: Tuesday, January 26th – 4pm – 5pm Presenter: Dr. Gregory Burke Chief Science Officer & Professor, Public Health Sciences – WFSOM Title: “Research Strategic Direction and Atrium Updates” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m8ec50ff3c9877aa8ee3ab0b1f57bc4f1 Meeting #: 178 336 4936 Password: awJBV7kWr24
Hypertension & Vascular Research Journal Club/Research in Progress Date/Time: Wednesday, January 27th – 1:30pm – 2:30pm Presenter: Tiffany Newman (Graduate Student) Title:“Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans” Webex: https://www.cell.com/cell/pdf/S0092-8674(20)31150-8.pdf Meeting number: 178 190 1820 Meeting Password: xgUbfan9f68
The Claude D Pepper Older Americans Independence Centers Coordinating Center – Co-hosting with the AGING Initiative - Webinar Date/Time: Wednesday, January 27th – 3pm – 4pm Presenters: Dr. Marcel Salive Dr. Andrea Gilmore-Bykovskyi Division of Geriatrics & Assistant Professor Clinical Gerontology School of Nursing National Institute of Aging University of Wisconsin-Madison Title: “Impacts of Implementation Research and Practice focused on Older Adults” Registration: https://wakehealth.webex.com/mw3300/mywebex/default.do?siteurl=wakehealth&service=6 Meeting #: 178 264 2401 Password: w7qXiMWFJ79
AFAR (American Federation for Aging Research) is hosting a free symposium “The Future is Now. Innovations in AI and Big Data for Healthspan and Longevity.” Tuesday, February 9th – 12pm – 2pm AFAR is bringing together leading experts to discuss how Omics research – which applies AI, big data, and systems research – is advancing biomedical research to help extend all of our years of health. Presenters include: Dr. Nir Barzilai (Scientific Director, AFAR) Dr. Morgan Levine (Assistant Professor – Pathology/Epidemiology – Yale School of Medicine) Dr. Amos Tanay (Professor – Dept of Computer Science and Applied Math & Dept of Biological Regulation – Weizmann Institute of Science) Bracken P. Darrell (President & Chief Executive Officer – Logitech) Dr. David A. Sinclair (Professor – Dept of Genetics & Director, Paul F. Glenn Center for Biological Mechanisms of Aging – Harvard) Dr. Oscar Vivas (Research Assistant Professor – University of Washington) RSVP by February 2nd here.
Recent Publications
Rocco MV,*Comeau ME, *Marion MC, Freedman BI, Hawfield AT, Langefeld CD, SPRINT Research Group. Effects of Intensive Systolic Blood Pressure Control on All-Cause Hospitalizations. Hypertension. 2020 Dec;76(6):1717-1724. PMCID: PMC7666020. https://doi.org/10.1161/hypertensionaha.120.15868
Batra SS, Levy-Sakin M, Robinson J, Guillory J, Durinck S, Vilgalys TP, Kwok P-Y, Cox LA, Seshagiri S, Song YS, Wall JD. Accurate assembly of the olive baboon (Papio Anubis) genome using long-read and Hi-C data. Gigascience. 2020 Dec 7;9(12):giaa134. PMICD: PMC7719865. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7719865/
Sequeira RC, Criswell T, Atala A, Yoo JJ. Microfluidic Systems for Assisted Reproductive Technologies: Advantages and Potential Applications. Tissue Eng Regen Med. 2020 Dec;17(6):787-800. PMCID: PMC7710813. https://doi.org/10.1007/s13770-020-00311-2
McLouth LE, Nightingale CL, Dressler EV, Snavely AC, Hudson MF, Unger JM, Kazak AE, Lee SJC, Edward J, Carlos R, Kamen CS, Neuman HB, Weaver KE. Current Practices for Screening and Addressing Financial Hardship within the National Cancer Institute’s Community Oncology Research Program. Cancer Epidemiol Biomarkers Prev. 2020 Dec 21;cebp.1157.2020. PMID: 33355237. https://doi.org/10.1158/1055-9965.epi-20-1157
Guo H, Deng N, Dou L, Ding H, Criswell T, Atala A, Furdui CM, Zhang Y. 3-D Human Renal Tublar Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening. ACS Biomater Sci Eng. 2020 Dec 14;6(12):6701-6709. PMID: 33320634. https://doi.org/10.1021/acsbiomaterials.0c01468
Member News
Dr. Wei Zhang – Cardiovascular Medicine Research Conference https://wakehealth.webex.com/wakehealth/ldr.php?RCID=06f4a184efe142459bbfe380dd22f2ed
Member Highlights
Nicholette (Palmer) Allred, PhD Associate Professor – Biochemistry Nicholette (Palmer) Allred, PhD, is a molecular biologist with a research focus on understanding the genomic architecture of complex diseases and underlying risk factors in minority populations. With an emphasis on metabolic disease, her research projects include type 2 diabetes (T2D), obesity, liver disease, nephropathy, and cardiovascular disease (CVD). She has applied diverse-omics approaches to understand disease pathophysiology including exome and whole genome sequencing, metabolomics in the setting of T2D to provide insight into the biological mechanisms involved in insulin resistance and cognitive decline. She is also involved in multiple large-scale collaborative projects, including the North Carolina Diabetes Research Center (NCDRC) where she serves as the Pilot and Feasibility Chair, the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program, the Genetic of Obesity-associated Liver Disease (GOLD) Consortium where she is a member of the Steering Committee, the Consortium of METabolomics Studies (COMETS) where she chairs the Diabetes and Obesity Working Group. At Wake Forest, she is a member of the Center for Precision Medicine, Center for Diabetes Obesity and Metabolism, Center for Biomedical Informatics, Sticht Center for Healthy Aging and Alzheimer’s Prevention and the Office of Women in Science. Selected Publications: https://www.ncbi.nlm.nih.gov/myncbi/nicholette%20d.allred.1/bibliography/public/ A noncoding variant near PPP1R3B promotes liver glycogen storage and MetS, but protects against myocardial infarction. https://doi.org/10.1210/clinem/dgaa855 Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4915581/ Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4407862/ Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Flucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS). http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6456957/ A genome-wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6594546/ Adiponectin Isoform Patterns in Ethnic-Specific ADIPOQ Mutation Carriers: The IRAS Family Study. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5529227/