Announcements
The Center for Precision Medicine has face masks. The masks are 3-Ply 3D Cotton with adjustable ear loops and the CPM logo digitally printed on them. According to Dr. Greg Hawkins and Dr. Tim Howard they are one of the most comfortable masks they’ve worn to date. If you are interested in obtaining a mask, please contact Ginger Pate grpate@wakehealth.edu to arrange pick up. We have 150 to give away, so it’s first-come-first-serve. If the demand is high we will place another order.
New York Stem Cell Foundation – Robertson Neuroscience Investigator Awards NYSCF is soliciting applications from early career investigators for awards in neuroscience. The goal of the initiative is to foster innovative scientists whose pioneering approaches have the potential to transform the field of neuroscience. Applicants are invited to apply from all fields in neuroscience. Applications from neuroscientists with human systems focused research (genomic, epidemiological, imaging, real-world data, etc.) are encouraged.o Award provides $1.5 million over 5 years. (no institutional overhead) Submission deadline is February 17, 2021 by 5pm EST For complete information – www.nyscf.org/neuroaward
The Chan Zuckerberg Initiative invites applications for Visual Proteomics Imaging The Initiative invites applications for challenge grants in the field of Visual Proteomics. This RFA aims to advance technology directed at the goal of obtaining near-atomic resolution readouts inside the cell. Submission deadline is February 17, 2021 by 8pm PST Awards will be 2.5 years in duration with a start date no earlier than August 1st. For complete information - https://chanzuckerberg.com/rfa/visual-proteomics/
NIDA – Notice of Special Interest: Effects of smoking and vaping on the risk and outcome of COVID-19 InfectionThis NOSI encourages research to understand the risks that smoking/vaping tobacco or marijuana may have on acquiring the COVID-19 infection. The medical consequences, co-morbidity, and complication of COVID-19 infection in individuals who smoke/vape. The medical consequences of COVID-19 individuals who smoke/vape with comorbid conditions such as: SUD, HIV, and other immunosuppressive diseases, mental health disorders, diabetes mellitus, obesity, cardiovascular, pulmonary, renal, and hepatic pathologies, as well as cancer. NOT-DA-21-011 Dues dates are on or after June 5, 2021 For complete information - http://grants.nih.gov/grants/guide/notice-files/NOT-DA-21-011.html
Foundational Funding Opportunities https://ctsi.wakehealth.edu/-/media/WakeForest/CTSI/Files/Funding-Opportunities/NIH-Funding-Opportunities.pdf
NIH Funding Opportunities https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm
Internal Pilots and other External Opportunities https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=61dfdfd0c9
Upcoming Events
Center for Diabetes, Obesity, and Metabolism – Virtual Seminar Date/Time: Monday, February 1st – 4pm Speaker: Kristina Henderson Lewis, MD, MPH, SM Associate Professor – Epidemiology and Prevention, WFSOM Title:“From Research to Reality: Lessons learned implementing an HER-based screener for sugary drink consumption” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=mf1394c0571a3b01f588f6e94016f4fb7 Meeting #: 178 615 6114 Password: CDOM
MMTS 782 – Molecular Medicine Journal Club – Webex presentation Date/Time: Friday, February 5th – 10 – 11 am Speaker: Lanazha Belfield PhD Student – matriculated 2017 Research mentor: D. Clark Files – Pulmonary Title:“Therapeutic Glucocorticoids Prevent Bone Loss but Drive Muscle Wasting When Administered in Chronic Polyarthritis” Fenton, CG et al., Arthritis Res & Therapy (2019)21:182 Link to paper: https://wakehealth.sharepoint.com/sites/MolecularMedicineResearch/Journal%20Articles/Forms/2019.aspx?viewid=fb520096%2D254c%2D457f%2Da8da%2D6c57a9dfb122&id=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles%2FJournal%20Club%202%205%2021%2Epdf&parent=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m78492e974abffa3b36c84066419a8ff
Recent Publications
Eber MR, Park SH, Contino KF, Patel CM, Hsu F-C, Shiozawa Y. Osteoblasts derived from mouse mandible enhance tumor growth of prostate cancer more than osteoblasts derived from long bone. J Bone Oncol. 2020 Dec 30;26:100346. PMCID: PMC7779864. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7779864/
*Song Q, Su J, Miller LD, Zhang W. scLM: automatic Detection of Consensus Gene Clusters Across Multiple Single-cell Datasets. Genomics Proteomics Bioinformatics. 2020 Dec 23;S1672-0229(20)30142-X. PMID: 33359676. https://doi.org/10.1016/j.gpb.2020.09.002
Dewi FN, JM Cline. Nonhuman primate model in mammary gland biology and neoplasia research. Lab Anim Res. 2021 Jan5;37(1):3. PMCID: PMC7784333. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7784333/
Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, Lee J, Furdui CM, Singh R, Hsu F-C, Kim J, Whitlow CT, Nader MA, Deep G. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine. 2021 Jan ;63:103192. PMCID: PMC7804975. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7804975/
Conley CEW, Mattacola CG, Jochimsen KN, Dressler EV, Lattermann C, Howard JS. A Comparison of Neuromuscular Electrical Stimulation Parameters for Postoperative Quadriceps Strength in Patients After Knee Surgery: A Systematic Review. Sports Health. 2021 Jan 11;1941738120964817. [Online ahead of print] PMID: 33428557. https://doi.org/10.1177/1941738120964817
Member News
Victoria Chan – a 2019 CPM summer intern in Dr. Andrew South’s lab, will be nominated by Dr. Marion Eppler for the Robert H. Wright Service Leadership Award. This most prestigious award sponsored by the ECU Alumni Association, recognizes the four top graduating seniors at Spring Commencement.
Welcome to Kip Zimmerman, PhD, Postdoctoral Fellow in the Olivier Lab. Kip Zimmerman recently joined the Olivier lab as a postdoc. Kip is a biostatistician with an interest in applying and developing statistical methods to identify genomic drivers of disease. He earned his doctorate in Molecular Genetics and Genomics from the Wake Forest Graduate School of Arts and Sciences in 2020 under the mentorship of Dr. Carl Langefeld. His dissertation primarily focused on hypothesis testing for differential gene expression in single-cell RNA-sequencing studies. As a postdoc in Dr. Olivier’s lab, Kip will focus on assembling computational pipelines for the analysis of proteomic and metabolomic data generated in the Olivier lab. In addition, he will concentrate on maturing statistical methods for integrating metabolomic data together proteomic and transcriptomic data in an effort to understand complex biological processes at more than one individual level of omics data. Welcome to the Center for Precision Medicine!
Member Highlights
Graça Almeida-Porada, MD, PhD Professor, Wake Forest Institute for Regenerative Medicine Professor, Biomedical Engineering Professor, Hematology and Oncology Dr. Almeida-Porada’s research focuses on the development of cellular and gene delivery platforms to treat genetic and immune-mediated diseases. She is particularly interested in improving the outcome of stem cell transplantation and gene therapy in fetal and neonatal patients with genetic disorders, and in developing therapies for children with immune-mediated diseases. She is currently supported by NHLBI to investigate prenatal (R01) and post-natal (R01) therapies in Hemophilia A and to manufacture a cell and gene therapy platform to treat hemophilia A (U01). She is the Director of the Fetal Research and Therapy Center at Wake Forest Institute for Regenerative Medicine. She is the co-editor-in-chief of Current Stem Cell Reports and the co-founder of the International Fetal Transplantation and Immunology Society. Papers: https://pubmed.ncbi.nlm.nih.gov/?term=Almeida-Porada+&sort=date https://pubmed.ncbi.nlm.nih.gov/?term=Porada+G&sort=date https://pubmed.ncbi.nlm.nih.gov/?term=Almeida%20GD&sort=date (#13;#14)