Announcements 

Recipient of 2020 Center for Precision Medicine Pilot Award Joel Joseph, MD Internal Medicine Residency, PGY-3 ”Use of Whole Genome Sequencing in Familial Colorectal Cancers” Subjects will be recruited and collection of DNS samples completed. Sequencing and data analysis of the whole genome will be performed for familial colorectal cancers.      10/01/2020 – 05/31/2021   $26,500

The 35th Annual Medical Student Research Day (MSRD) Date/Time: Wednesday, Oct 14th  - 1pm – 3 pm Info: Opportunity for students to showcase their research projects in front of faculty, staff, and colleagues. Keynote address will be made by John Buse, MD, PhD (UNC School of Medicine) Dr. Buse is the Chief, Division of Endocrinology and Director of the Diabetes Center at UNC.  For more information: https://ctsi.wakehealth.edu/Education-and-Training/MSRD?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=8352ce8b3c-EMAIL_CAMPAIGN_2020_01_02_07_05_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-8352ce8b3c-194798127 Registration: MUST PRE-REGISTER!   Registration Link: https://redcap.link/MSRD2020

Wake Forest Pepper Center Pilot RFA – Funding Opportunity in Geriatric Research Pilot and Exploratory Studies Research Program Funding Announcement/Pepper OAIC: “Integrating pathways affecting physical function for new approaches to disability treatment and prevention” Due Date:  LOI (Monday, Oct 5th by 5pm)           Full Application (Friday, Nov 6th by 5pm) Info: The WF Pepper Pilot Studies Program promotes promising new research ideas by providing funds for generation of preliminary data for the development of grant applications leading to external funding of behavioral, cognitive, genomic, metabolic, and other factors which contribute to age-related physical function decline, or progression to disability. A major goal is the development and testing in clinical or pre-clinical studies of novel interventions which target contributors to age-related decline in physical function in order to prevent or reverse the progression to disability. (see flyer for full details)

BrightFocus Foundation – Alzheimer’s Disease Research Program Standard Award Due Date: November 10th Info: The goal of the program is to accelerate our understanding of the biological mechanisms underlying Alzheimer’s Disease and related dementias as well as innovative approaches to better diagnose, prevent or delay the progress of the disease. Preference is made for exciting pilot projects that would not, at their present stage, be competitive for large government or industry awards. Award duration is up to 3 yrs at $100,000 per year. Link: https://www.brightfocus.org/grants/request-proposal-alzheimers-disease-research-program?utm_source=eAlert&utm_medium=email&utm_campaign=ADR-Grant-Proposal&sm_guid=MzQ5NTUxfDExNjM1MDA3fC0xfGNkYW5pZWxAd2FrZWhlYWx0aC5lZHV8Mjc5OTQ4MHx8MHwwfDc2MDMxNzUzfDgzN3ww&utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=16a75e745b-EMAIL_CAMPAIGN_2020_04_14_08_58_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-16a75e745b-

CTSI Internal and External funding opportunities link: https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master%3A+Research+Rundown+%2F+Funding&utm_campaign=700f42117c-EMAIL_CAMPAIGN_2020_01_02_07_05_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-700f42117c-194798127

Upcoming Events

Comparative Medicine Research Strategy – Virtual Seminar (flyer attached) Date/Time:     Tues, September 22nd – 3:30pm – 4:30pm Presenter:       Clemens Duerrschmid, PhD (Technical Application Scientist, Akoya Biosciences) Title:   “High-Dimensional Spatial Biology: PhenopticsTM and CODEX® Platforms for Multiplex Biomarker Visualization” Webex Info:    Meeting #: 171 095 2905      Meeting password: gYMQDuD27m5                        https://wakehealth.webex.com/wakehealth/j.php?MTID=m1e04f644fa5ef0be54f0abcef45b8370                         Join by phone: +1-415-655-0001 US Toll

Precision Medicine Leaders Summit – Virtual Series – Precision Diagnostics Date/Time:     Sept 24-25, 2020 Info:                Discussion topics include Diagnostics, COVID-19, Vaccines, Community Oncology, Population Health, Precision Oncology, AI, Pharmacogenomics, and Pathology. (see attached flyer) Info and Registration Link: https://www.precisionmedicineleaderssummit.com/  REGISTRATION REQUIRED

Appalachian Translational Research Network Community-engaged Research in Translational Science: Innovations to Improve Health in Appalachia CTSI is hosting the 10th Annual ATRN Health Summit (VIRTUAL) Date/Time:     Sept 22-23, 2020 (Tuesday, 9/22/20 – 9:45am – 12:20pm)  (Wednesday, 9/23/20 – 9:45am – 12:45pm) Info;                See Attached PDF for Summit information Link:                Registration & Abstract Submission information: https://go.northwestahec.wakehealth.edu/atrn2020?utm_source=Master%3A+Research+Rundown+%2F+Funding&utm_campaign=c5a95db682-EMAIL_CAMPAIGN_2020_01_02_07_05_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-c5a95db682-194798127

Molecular Medicine Journal Club (MMTS 781)  - Webex Date/Time:     Friday, Sept 25th – 12:15pm  - 1:15pm Presenter:       Allison Meyers                         3rd year PhD Student – Matriculated 2017                         Mentor(s): Dr. Xuewei Zhu & Dr. Charles McCall                         Program: Molecular Medicine and Translational Sciences Talk Title:        “Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response Through a HIF-la/Glycolysis-Dependent Axis”        Codo, A et al. Cell Metabolism 32, 437-446, Sept 1, 2020 Webex Info:    Meeting #: 171 652 6202 Meeting password: xH9JDQsMH33 Join meeting [wakehealth.webex.com] Join by phone: +1-415-655-0001 Join by video system: 1716526202@wakehealth.webex.com 

Recent Publications

Ø  Wu FL, Strand AI, Cox LA, Ober C, Wall JD, Moorjani P, Przeworski M. A Comparison of Humans and Baboons Suggests Germline Mutation Rates do not Track Cell Divisions.  PloS Biol. 2020 Aug 17; 18(8):e3000838.  [Online ahead of print] PMID: 32804933. https://doi.org/10.1371/journal.pbio.3000838 

Ø  *Nataraj BH, Ali SA, Behare PV, Yadav H. Postbiotics-parabiotics: The New Horizons in Microbial Biotherapy and Functional Foods. Microb Cell Fact. 2020 Aug 20; 19(1):168. PMCID: PMC7441679. https://doi.org/10.1186/s12934-020-01426-w  

Ø  Ding H, Kiguchi N, Perrey DA, Nguyen T, Czoty PW, Hsu F-C, Zhang Y, Ko M-C. Antinociceptive, reinforcing, and pruritic effects of the G-protein signaling-biased mu opioid receptor agonist PZM21 in non-human primates. Br J Anaesth. 2020 Aug 17;S0007-0912(20)30551-1. [Online ahead of print] PMID: 32819621. https://doi.org/10.1016/j.bja.2020.06.057  

Ø  Williams GR, Weaver KE, Lesser GJ, Dressler E, Winkfield KM, Neuman HB, Kazak AE, Carlos R, Gansauer LJ, Kamen CS, Unger JM, Mohile SG, Klepin HD. Capacity to Provide Geriatric Specialty Care for Older Adults in Community Oncology Practices. Oncologist. 2020 Aug 21. [Online ahead of print] PMID: 32820842. https://doi.org/10.1634/theoncologist.2020-0189  

Ø  Moaven O, Miller LD, Levine EA. ASO Author Reflections: Molecular Profiling Can Provide Personalized Clinical Guidance in the Management of Peritoneal Malignancies. Ann Surg Oncol. 2020 Aug 4. [Online ahead of print] PMID: 32749622. https://doi.org/10.1245/s10434-020-08980-y  

Member Highlights

      New Members - Center for Precision Medicine ·         Sarah Cilvik, MD, PhD – Assistant Professor, Pediatrics – Neonatology ·         Sean Murphy, PhD – Assistant Professor, WF Institute of Regenerative Medicine ·         Kiran Solingapuram Sai, PhD – Assistant Professor, Radiology