Announcements

Foundation Funding Opportunities:  https://ctsi.wakehealth.edu/-/media/WakeForest/CTSI/Files/Funding-Opportunities/NIH-Funding-Opportunities.pdf  NIH Funding Opportunities: https://grants.nih.gov/grants/guide/WeeklyIndexMobile.cfm Precision Medicine Leaders Summit – RTP/Population Health Date/Time:     October 20-21, 2020 – 9:00am – 12:00pm Info:    The North Carolina Precision Health Collaborative in partnership with the Precision Medicine Leaders Summit, will gather renowned experts in precision health who are shaping the field today and for the future, particularly in the areas of Population Health. Speakers will include clinicians, industry experts and c-suite executives, academics, payers, bioinformaticians and policy influencers.             This is a two-morning virtual Summit where multi-stakeholders will discuss advancing the science behind, and the more routine implementation of, evidence-based precision medicine. A key feature of this Summit is the opportunities and outcomes between precision medicine and population health. Thought leaders will also provide guidance and roadmaps for addressing policy and other challenges holding back the field.             Web:    Full agenda:  agenda [marketing.ncbiotech.org] Registration (required):  registration [marketing.ncbiotech.org]

Upcoming Events

Center for Precision Medicine – Virtual Seminar Series Date/Time:     Thursday, Oct 1st – 12pm – 1pm Presenter:       David Crosslin, PhD, Assistant Professor, Biomedical & Health Informatics  University of Washington School of Medicine Talk Title:       “The Implementation of Genetic Medicine” Zoom Info:     https://us02web.zoom.us/j/81174785614?pwd=Qzc0TUkwMlhqNFVrVlpCK3k2TXlWZz09                         Meeting ID:    811 7478 5614                        Passcode:        029986

Comparative Medicine Research Strategy Date/Time:     Tuesday, Sept 29th – 3:30pm – 4:30pm Presenter:       Matthew Quinn, PhD    Assistant Professor – Pathology/Comparative Medicine Talk Title;       Upcoming R35 Proposal: Mechanisms and Consequences of Metabolic Adaptations to SepsisWebEx Info:   Meeting #: 171 477 1984 Password: 7M3x9XeEWPm https://wakehealth.webex.com/webappng/sites/wakehealth/meeting/download/aa7500be8ad04b4faaab77a40b9c354a?siteurl=wakehealth&MTID=m4f9e512eac4f9a397b3492b9d5e60fa9 Join from mobile: +1-415-655-0001,,1714771984## Join by phone: +1-415-655-0001 US Toll 

Molecular Medicine Journal Club (MMTS 781) – Webex Date/Time:     Friday, Oct 2nd – 12:15pm – 1:15pm Presenter:       Tom Forshaw, PhD  Postdoctoral Fellow 2018 – Current      Mentor: Dr. Cristina Furdui                         Dept: Molecular Medicine Talk Title:        “Targeting NOX4 Alleviates Sepsis-Induced Acute Lung Injury via Attenuation of Redox-Sensitive Activation of CaMKII/ERK1/2MLCK and Endothelial Cell Barrier Dysfunction”                         Jiang, J. et al. Redox Biology 36, 2213-2317, July, 2020 Link to Paper: https://wakehealth.sharepoint.com/sites/MolecularMedicineResearch/Journal%20Articles/Forms/2019.aspx?viewid=44c12f73%2D6369%2D4467%2Da687%2Dd1094ec260ca&id=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles%2FJournal%20Club%2010%202%2020%2Epdf&parent=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles WebEx Info:   Meeting #: 171 652 6202 Meeting password: xH9JDQsMH33 Join meeting [wakehealth.webex.com] Join by phone: +1-415-655-0001 Join by video system: 1716526202@wakehealth.webex.com

Center for Diabetes, Obesity, and Metabolism – Seminar – Webex Date/Time:     Monday, Oct 5th – 4pm – 5pm Presenter:      Miranda E. Orr, PhD (Assistant Professor, Gerontology & Geriatric Medicine) Talk Title:       “Tau protein expression mediates obesity and insulin resistance induced cellular senescence” WebEx info:   Meeting #: 171 921 7114                        Password: CDOM

Recent Publications

Ø  Stopyra JP, Snavely AC, Lenoir KM, Wells BJ, Herrington DM, Hiestand BC, Miller CD, Mahler SA. HEART Pathway Implementation Safely Reduces Hospitalizations at One Year in Patients with Acute Chest Pain.  Ann Emerg Med. 2020 Jul 28;S0196-0644(20)30406-6. [Online ahead of print] PMID: 32736933. https://doi.org/10.1016/j.annemergmed.2020.05.035  

Ø  Lessey BA. Extracellular vesicles: a new understanding of endometrial receptivity? Fertil Steril. 2020 Aug; 114(2):287. PMID: 32622658. https://doi.org/10.1016/j.fertnstert.2020.05.007 

Ø  Beavers KM, Neiberg RH, Kritchevsky SB, Nicklas BJ, Kitzman DW, Messier SP, Rejeski WJ, Ard JD, Beavers DP. Association of Sex or Race with the Effect of Weight Loss on Physical Function: A Secondary Analysis of 8 Randomized Clinical Trials. JAMA Netw Open. 2020 Aug 3;3(8):e2014631. PMCID: PMC7442923.  https://doi.org/10.1001/jamanetworkopen.2020.14631  

Ø  Sharma NK, *Comeau ME, Montoya D, Pellegrini M, Howard TD, Langefeld CD, Das SK. Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans. Diabetes. 2020 Sept 14:db200117. [Online ahead of print] PMID: 32928872. https://doi.org/10.2337/db20-0117  

Ø  Wosiski-Kuhn M, Caress JB, Cartwright MS, Hawkins GA, Milligan C. Interleukin 6 (IL6) level is a biomarker for functional disease progression within IL6R358 Alavariant groups in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Sept 14;1-12. [Online ahead of print] PMID: 32924606. https://doi.org/10.1080/21678421.2020.1813310

Member Highlights

      New Members - Center for Precision Medicine ·         Sarah Cilvik, MD, PhD – Assistant Professor, Pediatrics – Neonatology ·         Sean Murphy, PhD – Assistant Professor, WF Institute of Regenerative Medicine ·         Kiran Solingapuram Sai, PhD – Assistant Professor, Radiology